"I can tell when people are reviewing my film and when they're reviewing me personally," the pop star told a packed press conference at the Toronto International Film Festival on Monday.
"I welcome criticisms of my film when it's viewed as an artistic form, and not when people are mentioning things about my personal life, or my achievements in any other field, because they're irrelevant to the film.
"So when they stick to the film, I do care. I mean, I pay attention to it."
Early reviews of the ambitious film have been decidedly mixed, with one scathing notice from the U.K.'s Guardian summing it up as "an extraordinarily silly, preening, fatally mishandled film" in a one-star takedown.
For her part, Madonna knew the movie would be a challenge. She said she was interested in making "W.E." even before she crafted her 2008 directorial debut, "Filth and Wisdom," but didn't feel ready to take on the complex project at the time.
"I felt like I needed to tackle something much simpler and really understand the technical aspects of filmmaking before I took it (on)," said Madonna, clad in a vibrant red blouse and tight black skirt.
"W.E." jumps back and forth through time to tell two stories: Andrea Riseborough plays Wallis Simpson, the controversial American whose romance with Edward VIII ultimately led to his abdication of the throne, while Australian actress Abbie Cornish portrays a downcast modern woman who is obsessed with her.
Madonna involved herself in virtually every part of "W.E.," from music to the script (which she co-wrote) to the lush set designs and intricate costumes. She says she even liked to help dress her actors every day, "fine-tuning" their hair and clothes.
"Finding an excuse to touch them, basically, was my ritual," she said.
Added Riseborough: "It was very important, because we had a sense of connection before we began."
And Madonna threw herself into the research process fully. In her own words, she was "fascinated" by Simpson. She was an unpopular figure to many, yet "W.E." takes pains to illustrate how much Simpson sacrificed in her romance with royalty, surrendering her privacy and her freedom while earning the scorn of millions of Brits.
"She was and is a very provocative character in the history of world politics and the world of fashion," said Madonna, who wore a gold "W.E." necklace that she said was a gift from her staff.
"She is a mysterious, enigmatic creature. Not conventionally beautiful, not young, twice divorced, not anything fabulous about her background, and somehow she managed to capture the heart of the man who, at the time, held the most important position in the world. That story intrigued me immensely and I wanted to understand it."
Rumours have long swirled that Simpson was a Nazi sympathizer, which Madonna seemed to address indirectly on Monday.
"I was interested in the concept of the cult of celebrity, which we are all consumed with now, and the idea is that there were so many rumours that are now believed to be true about Wallis Simpson, and when I investigated her story, there were so many of them that I could find no empirical evidence stating that they were true," she said.
Continued...